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Post-translational Modifications
News & Events
Post-translational Modifications (PTM) can be identified by mass spectrometric techniques and database searching of tandem MS data.
A list of known PTM's can be found on unimod.org it has about 1000 entries. Some of the most common PTM's are: phosphorylation, methylation, acetylation, glycosylation. Because of the often low stoichiometry of the modification, proteins or peptides often have to be enriched. IMAC (immobilised metal affinity chromatography) and TiO2 (Titanium dioxide) are examples for phosphopeptide enrichment.
Support Modes
Screening for post-translational modifications is available as Analytical Service and as User lab project.
Contacts
Analytical Service:
Rene Brunisholz - Protein Service
Peter Hunziker - Protein Service
Peter Gehrig - user lab
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